Synthesis, polymorphism, and insecticidal activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate against Anopheles arabiensis mosquito.
Venugopala, Katharigatta Narayanaswamy
Nayak, Susanta K.
Gleiser, Raquel M.
Sanchez-Borzone, M. E.
Garcia, D. A.
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Copyright: 2016. Wiley Online Library. Due to copyright restrictions, only the abstract is available. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in Chemical Biology & Drug Design, Vol 88, No 1. Pp 88-96. http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12736/full
Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector-borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In this study, pyrimido[2,1-b]quinazoline derivative DHPM3 has been synthesized by three-step chemical reaction and screened for larvicide, adulticide, and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate.
Venugopala, K.N. et al. 2016. Synthesis, polymorphism, and insecticidal activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate against Anopheles arabiensis mosquito.Chemical Biology and Drug Design. 88(1): 88-96.