Please use this identifier to cite or link to this item: http://hdl.handle.net/10321/2461
Title: Exploring the potential reservoirs of non specific TEM beta lactamase (blaTEM) gene in the Indo-Gangetic region : a risk assessment approach to predict health hazards
Authors: Singh, Gulshan 
Vajpayee, Poornima 
Rani, Neetika 
Amoah, Isaac Dennis 
Stenström, Thor-Axel 
Shanker, Rishi 
Keywords: Environmental reservoirs;blaTEM gene;Molecular beacon;Quantitative PCR;β-lactamase resistance
Issue Date: 2016
Publisher: Elsevier
Source: Singh, G. et al. 2016. Exploring the potential reservoirs of non specific TEM beta lactamase (blaTEM) gene in the Indo-Gangetic region : a risk assessment approach to predict health hazards. Journal of Hazardous Materials. 314: 121-128.
Abstract: The emergence of antimicrobial resistant bacteria is an important public health and environ-mental contamination issue. Antimicrobials of -lactam group accounts for approximately two thirds, by weight, of all antimicrobials administered to humans due to high clinical efficacy and low toxicity. This study explores -lactam resistance determinant gene (blaTEM) as emerging con-taminant in Indo-Gangetic region using qPCR in molecular beacon format. Quantitative Microbial Risk Assessment (QMRA) approach was adopted to predict risk to human health associated with consumption/exposure of surface water, potable water and street foods contaminated with bac-teria having blaTEM gene. It was observed that surface water and sediments of the river Ganga and Gomti showed high numbers of blaTEM gene copies and varied significantly (p < 0.05) among the sampling locations. The potable water collected from drinking water facility and clinical set-tings exhibit significant number of blaTEM gene copies (13 ± 0.44–10200 ± 316 gene copies/100 mL).
URI: http://hdl.handle.net/10321/2461
ISSN: 0304-3894 (print)
1873-3336 (online)
Appears in Collections:Research Publications (Academic Support)

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