Please use this identifier to cite or link to this item: http://hdl.handle.net/10321/983
Title: Evaluation of enantioresolution of (±)-catechin using electrokinetic chromatography and molecular docking
Authors: Sabela, Myalowenkosi Innocent 
Singh, Parvesh 
Gumede, Njabulo Joyfull 
Bisetty, Krishna 
Sagrado, Sagrado
Keywords: Enantioresolution;Electrokinetic chromatography (EKC);Molecular docking
Issue Date: 2012
Publisher: SRP
Source: Sabela, M.I., Singh, P., Gumede, N.J., Bisetty, K. and Sagrado, S. 2012. Evaluation of Enantioresolution of (±)-Catechin using Electrokinetic Chromatography and Molecular Docking." Journal of Scientific Research in Pharmacy. 1(2): 1-4.
Abstract: This study involves the enantioresolution of (±) catechin with the highly sulphated beta cyclodextrin (HS-β-CD) as a chiral selector using capillary electrophoresis (CE). The purpose of this study was to be tter understand enantioresolution amongst host-guest interactions. Furthermore, molecular docking was carried out to elucidate the mechanism of the enantioselective separations of (±) catechin enantiomers obtained in Electrokinetic chroma tography (EKC). A large difference in the interaction energies observed between the two enantiomers represents significant enantiodifferentiation. Our results also suggest that the host-guest interactions between the phenyl ring of the ligand and the open cavity of the HS-β-CD are due mainly to hydrophobic interactions. Interestingly, the stronger interactions observed with (+)-catechin is consistent with the elution order observed in the CE experiments.
URI: http://hdl.handle.net/10321/983
ISSN: 2277-9469
Appears in Collections:Research Publications (Applied Sciences)

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