Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/1083
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dc.contributor.authorReddy, Poovendhreeen_US
dc.contributor.authorNaidoo, Rajen N.en_US
dc.contributor.authorChuturgoon, Anil A.en_US
dc.contributor.authorAsharam, Kareshmaen_US
dc.contributor.authorPhulukdaree, Alisaen_US
dc.contributor.authorGounden, Shivonaen_US
dc.date.accessioned2014-06-24T09:57:04Z
dc.date.available2014-06-24T09:57:04Z
dc.date.issued2014-04-
dc.identifier.citationReddy, P, Naidoo, R.N., Chuturgoon, A., Asharam, K., Phulukdaree, A. and Gounden, S. 2014. Effect of the TNF α-308 polymorphism on birth outcomes among South African women. Journal of Advances in Biomedical Studies. 1(1): 21-26.en_US
dc.identifier.issn2373-1222-
dc.identifier.urihttp://hdl.handle.net/10321/1083-
dc.description.abstractThe −308 G/A promoter polymorphism in the tumor necrosis factor-alpha (TNF- α) gene has been extensively studied as a potential biomarker for pregnancy outcomes, but results tend to be population specific. The aim of this study was to evaluate the association of the TNF α-308 polymorphism with preterm birth (PTB) and low birth weight (LBW) in a cohort of South African women enrolled in a prospective pregnancy study. The Mother and Child Environmental cohort (MACE) pilot study was done in Durban, KwaZulu-Natal during 2010-2011 with 100 pregnant women recruited. Demographic, exposure and prenatal clinical data was collected during the third trimester, maternal and infant hospital records at delivery were reviewed. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine the TNF-α -308 genotype. Plasma TNF-α concentration was measured using the human TNF-α Max Standard™ ELISA kit (Bio-legend). The polymorphic TNF-α GA+AA genotype was found among 35% of mothers. Mean birth weight was significantly lower among mothers with the TNF-α AG+AA genotype (p<0.05). Mothers who delivered LBW infants (<2500g) showed a significantly higher mean TNF- α level compared to mothers with normal birth weight deliveries. In addition, mothers with the TNF-α AG+AA genotype had a statistically significant drop in birth weight (β= -273.6; SE105.8; CI: -0.9,-1.35). While the TNF-α A allele was not associated with PTB, it was significantly associated with low birth weight in this study. Early identification of such immunological biomarkers may facilitate prevention of adverse pregnancy outcomes.en_US
dc.format.extent6 pen_US
dc.language.isoenen_US
dc.publisherJABSen_US
dc.relation.ispartofJournal of advances in biomedical studies-
dc.subjectTNF α-308en_US
dc.subjectGenetic polymorphismen_US
dc.subjectBirth cohorten_US
dc.subjectBirth outcomesen_US
dc.titleEffect of the TNF α-308 polymorphism on birth outcomes among South African womenen_US
dc.typeArticleen_US
dc.publisher.urihttp://www.jabsdirect.com/article/view/13462en_US
dc.dut-rims.pubnumDUT-004029en_US
local.sdgSDG05-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
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