Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/1456
DC FieldValueLanguage
dc.contributor.authorGovender, Nalini-
dc.contributor.authorNaicker, Thajasvarie-
dc.contributor.authorMoodley, Jagidesa-
dc.date.accessioned2016-04-07T05:29:52Z-
dc.date.available2016-04-07T05:29:52Z-
dc.date.issued2015-
dc.identifier.citationGovender, N.; Naicker, T. and Moodley, J. 2015. Endoglin in HIV-associated preeclamptic placentae. Hypertens Pregnancy. Vol 34(3) : 342-354.en_US
dc.identifier.issn1525-6065-
dc.identifier.urihttp://hdl.handle.net/10321/1456-
dc.descriptionCopyright: 2015. Taylor & Francis. Due to copyright restrictions, only the abstract is available. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in Hypertension in Pregnancy, Volume 34, Issue 3, July 2015, pages 342-354en_US
dc.description.abstractObjective: To examine the placental immunoexpression of endoglin (Eng), in HIV-negative and HIV-positive normotensive (N and N+) and preeclamptic (P and P+) pregnancies at term, using immunohistochemistry and immunoelectron microscopy. Results: Strong Eng immunoreactivity was observed within endothelial cells, syncytio-and cyto-trophoblast cell populations. All extravillous trophoblast cells were immuno-positive for Eng. Subcellularly, gold particles were immunolocalised within the endoplasmic reticulum, and mitochondria. Immunoexpression of Eng differed signifi-cantly between exchange (p = 0.02) and conducting villi (p50.001). A higher Eng immunoexpression was observed in both villi types of the preeclamptic compared to normotensive groups. Irrespective of pregnancy type (normotensive versus PE), there was no significant effect of HIV status on Eng immunoexpression within the exchange and conducting villi. Conclusion: The immunostaining of Eng within the endothelial cells, syncytio-, cyto- and extravillous trophoblast cell populations of HIV-associated preeclamptic placentae is novel. Endoglin and its soluble component remains an area for dynamic placental exploration in preeclampsia development.en_US
dc.format.extent13 pen_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofHypertension in pregnancy (Online)-
dc.subjectImmunostainingen_US
dc.subjectEngen_US
dc.subjectHIVen_US
dc.subjectPreeclampsiaen_US
dc.subjectPlacentaen_US
dc.titleEndoglin in HIV-associated preeclamptic placentaeen_US
dc.typeArticleen_US
dc.publisher.urihttp://www.tandfonline.com/doi/full/10.3109/10641955.2015.1046603en_US
dc.dut-rims.pubnumDUT-004885en_US
local.sdgSDG03-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextnone-
item.cerifentitytypePublications-
Appears in Collections:Research Publications (Health Sciences)
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