Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/2480
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dc.contributor.authorChetty, Nevendra K.en_US
dc.contributor.authorChonco, Louisen_US
dc.contributor.authorIjumba, Nelson M.en_US
dc.contributor.authorChetty, Leonen_US
dc.contributor.authorGovender, Thavendranen_US
dc.contributor.authorParboosing, Raveenen_US
dc.contributor.authorDavidson, Innocent Ewaenen_US
dc.date.accessioned2017-08-01T12:33:32Z-
dc.date.available2017-08-01T12:33:32Z-
dc.date.issued2016-09-
dc.identifier.citationChetty, N.K. et al. 2016. Analysis of current Pulses in HeLa-Cell Permeabilization due to high voltage DC corona discharge. IEEE Transactions on NanoBioscience. 15(6): 526-532.en_US
dc.identifier.issn1536-1241-
dc.identifier.issn1558-2639 (online)-
dc.identifier.urihttp://hdl.handle.net/10321/2480-
dc.description.abstractCorona discharges are commonly utilized for numerous practical applications, including bio-technological ones. The corona induced transfer of normally impermeant molecules into the interior of biological cells has recently been successfully demonstrated. The exact nature of the interaction of the corona discharge with a cell membrane is still unknown, how-ever, previous studies have suggested that it is either the electric fields produced by ions or the chemical interaction of the reactive species that result in the disruption of the cell membrane. This disruption of the cell membrane allows molecules to permeate into the cell. Corona discharge current constitutes a series of pulses, and it is during these pulses that the ions and reactive species are produced. It stands to reason, therefore, that the nature of these corona pulses would have an influence on the level of cell permeabilization and cell destruction. In this investigation, an analysis of the width, rise-time, characteristic frequencies, magnitude, and repetition rate of the nanosecond pulses was carried out in order to establish the relationship between these factors and the levels of cell membrane permeabilization and cell destruction. Results obtained are presented and discussed.en_US
dc.format.extent7 pen_US
dc.language.isoenen_US
dc.publisherIEEEen_US
dc.relation.ispartofIEEE transactions on nanobioscience (Online)en_US
dc.subjectCell permeabilizationen_US
dc.subjectCorona dischargeen_US
dc.subjectElec-troporationen_US
dc.subjectHigh voltage direct currenten_US
dc.subjectMolecular deliveryen_US
dc.titleAnalysis of current Pulses in HeLa-Cell Permeabilization due to high voltage DC corona dischargeen_US
dc.typeArticleen_US
dc.dut-rims.pubnumDUT-005711en_US
dc.description.availabilityCopyright: 2016. IEEE. Due to copyright restrictions, only the abstract is available. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in IEEE Transactions on NanoBioscience. 15(6): 526-532. https://www.ncbi.nlm.nih.gov/pubmed/27824575en_US
dc.identifier.doi10.1109/TNB.2016.2585624-
local.sdgSDG17-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextnone-
item.cerifentitytypePublications-
Appears in Collections:Research Publications (Engineering and Built Environment)
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