Please use this identifier to cite or link to this item:
https://hdl.handle.net/10321/2990
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Odun-Ayo, Frederick Oluwasheyi | en_US |
dc.contributor.author | Mellem, John Jason | en_US |
dc.contributor.author | Reddy, Lalini | en_US |
dc.date.accessioned | 2018-05-28T07:07:26Z | - |
dc.date.available | 2018-05-28T07:07:26Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Odun-Ayo, F. 2016. Improving the survival of probiotic in simulated conditions and azoxymethane-induced colon tumour bearing mice using modified citrus pectin-alginate microencapsulation. African Journal of Traditional, Complementary and Alternative Medicines. 13(2): 101-109. | en_US |
dc.identifier.issn | 0189-6016 (print) | - |
dc.identifier.issn | 2505-0044 (online) | - |
dc.identifier.uri | http://hdl.handle.net/10321/2990 | - |
dc.description.abstract | Background: For a probiotic to be viable it needs to be preserved at a recommended minimum level of 6–7 log10cfu/g in the product being consumed, as suggested by the International Dairy Federation. Different biopolymer matrices have been used for encapsulation of probiotic; however, loss of viability is still a challenge. Materials and Methods: Modified citrus pectin-alginate microbeads containing Lactobacillus acidophilus ATCC 4356 was developed. Efficiency of the microbeads was evaluated in simulated conditions of the gastrointestinal tract and in Balb/c mice induced with colon tumor. Genomic identification of faecal lactobacilli samples from treated mice was also performed. Results: The Modified citrus pectin-alginate probiotic microbeads significantly enhanced the viability of Lactobacillus acidophilus ATCC 4356 compared to the control (p< 0.05) both in vitro and in vivo. Exposure of the modified citrus pectin-alginate microbeads to 3 hours of simulated gastric juice resulted in 82.7% survival of L. acidophilus ATCC 4356. Also, the number of faecal lactobacilli in the modified citrus pectin-alginate probiotic treated mice increased by 10.2% after 28 days. Conclusion: Modified citrus pectin-alginate is a novel effective means of oral delivery of bacterial cells and bioactive compounds. Modified citrus pectin-alginate can be used in probiotic therapy which may improve the prevention of colon cancer. | en_US |
dc.format.extent | 9 p | en_US |
dc.language.iso | en | en_US |
dc.publisher | PKP Publishing Services Network | en_US |
dc.relation.ispartof | African Journal of Traditional Complementary and Alternative Medicine (Online) | en_US |
dc.subject | Modified citrus pectin | en_US |
dc.subject | Alginate | en_US |
dc.subject | Probiotic | en_US |
dc.subject | Microencapsulation | en_US |
dc.title | Improving the survival of probiotic in simulated conditions and azoxymethane-induced colon tumour bearing mice using modified citrus pectin-alginate microencapsulation | en_US |
dc.type | Article | en_US |
dc.publisher.uri | http://journals.sfu.ca/africanem/index.php/ajtcam/article/view/3364/2352 | en_US |
dc.dut-rims.pubnum | DUT-005830 | en_US |
dc.identifier.doi | http://dx.doi.org/10.4314/ajtcam.v13i2.13 | - |
local.sdg | SDG03 | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
Appears in Collections: | Research Publications (Applied Sciences) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Odun-Ayo_AJTCAM_Vol13#2_Pg101-109_2016.pdf | 1.52 MB | Adobe PDF | View/Open |
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