Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/3402
DC FieldValueLanguage
dc.contributor.authorNagaraja, SreeHarshaen_US
dc.contributor.authorVenugopala, Katharigatta Narayanaswamyen_US
dc.contributor.authorAnroop, Nairen_US
dc.contributor.authorRoopashree, Srinivasaen_US
dc.contributor.authorMahesh, Attimaraden_US
dc.contributor.authorJagadeesh, Hiremathen_US
dc.contributor.authorBandar, Al-Dhubiaben_US
dc.contributor.authorChandramouli, Ramnarayananen_US
dc.contributor.authorPottathil, Shinuen_US
dc.contributor.authorMukund, Handralen_US
dc.contributor.authorMicheline, Harounen_US
dc.contributor.authorChristophe, Tratraten_US
dc.date.accessioned2020-06-11T05:27:55Z-
dc.date.available2020-06-11T05:27:55Z-
dc.date.issued2019-12-27-
dc.identifier.citationNagaraja, S., Venugopala, K. N., Anroop, N., Roopashree, S.,Mahesh, A., Jagadeesh, H., Bandar, A., Chandramouli, R.,Pottathil, S., Mukund, H., Micheline, H., Christophe, T. 2019. An efficient, lung-targeted, drug-delivery system to treat asthma via microparticles. Drug Design, Development and Therapy, 2019(13): 4389-4403. doi:10.2147/DDDT.S216660.en_US
dc.identifier.issn1177-8881-
dc.identifier.urihttp://hdl.handle.net/10321/3402-
dc.description.abstractBackground: Chronic diseases such as diabetes, asthma, and heart disease are the leading causes of death in developing countries. Public health plays an important role in preventing such diseases to improve individuals’ quality of life. Conventional dosage schemes used in public health to cure various diseases generally lead to undesirable side effects and renders the overall treatment ineffective. For example, a required concentration of drug cannot reach the lungs using conventional methods to cure asthma. Microspheres have emerged as a confirmed drug-delivery system to cure asthma. Method: In this paper, a salbutamol-loaded poly lactic acid-co-glycolic acid-polyethylene glycol (PLGA-PEG) microsphere (SPP)-based formulation was prepared using a Buchi B-90 nanospray drier. Face-centered central composite design (CCD) was applied to optimize the spray-drying process. Results: The drug content and product yield were found to be 72%±0.8% and 86%±0.4%, respectively; drug release (91.1%) peaked for up to 12 hrs in vitro. Microspheres obtained from the spray dryer were found to be shriveled. The experiments were carried out and verified using various groups of rabbits. In our study, the particle size (8.24 μm) was observed to be an essential parameter for drug delivery. The in vivo results indicated that the targeting efficacy and drug concentration in the lung was higher with the salbutamolloaded PLGA-PEG SPP formulation (1,410.1±10.11 μg/g, 15 mins), as compared to the conventional formulation (92±0.56 μg/g, 10 min). The final product was stable under 5°C±2°C, 25°C±2°C, and 40°C±2°C/75%±5% relative humidity. In addition, these co-polymers have a good safety profile, as determined by testing on human alveolar basal epithelium A549 cell lines. Conclusion: Our results prove that microspheres are an alternative drug-delivery system for lung-targeted asthma treatments used in public health.en_US
dc.format.extent15 p.en_US
dc.language.isoenen_US
dc.publisherDove Medical Pressen_US
dc.relation.ispartofDrug design, development and therapyen_US
dc.subjectPolylactic acid-co-glycolic aciden_US
dc.subjectPublic healthen_US
dc.subjectSpray dryeren_US
dc.subjectMicrospheresen_US
dc.titleAn efficient, lung-targeted, drug-delivery system to treat asthma via microparticlesen_US
dc.typeArticleen_US
dc.date.updated2020-05-18T17:04:10Z-
dc.publisher.urihttps://doi.org/10.2147/DDDT.S216660en_US
dcterms.dateAccepted2019-10-17-
dc.identifier.doi10.2147/DDDT.S216660-
local.sdgSDG03-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextopen-
item.cerifentitytypePublications-
Appears in Collections:Research Publications (Applied Sciences)
Files in This Item:
File Description SizeFormat
SreeHarsha_DDDT_Vol2019#13_Pg4389-4403_2019.pdf6.44 MBAdobe PDFView/Open
Show simple item record

Page view(s)

772
checked on Dec 22, 2024

Download(s)

97
checked on Dec 22, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.