Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/3813
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dc.contributor.authorAttimarad, Maheshen_US
dc.contributor.authorVenugopala, Katharigatta Narayanaswamyen_US
dc.contributor.authorShafi, Sheebaen_US
dc.contributor.authorBalgoname, Abdulmalek Ahmeden_US
dc.contributor.authorAltaysan, Abdulrahman Ibrahimen_US
dc.date.accessioned2022-01-26T07:35:31Z-
dc.date.available2022-01-26T07:35:31Z-
dc.date.issued2022-01-12-
dc.identifier.citationAttimarad, M, Venugopala, K.N., Shafi, S., Balgoname, A.A. and Altaysan, A.I. 2022. Smart spectrophotometric method development for simultaneous estimation of antidiabetic drugs in formulations. Indian Journal of Pharmaceutical Education and Research. 56(1): 224-231. doi:10.5530/ijper.56.1.26en_US
dc.identifier.issn0019-5464 (Online)-
dc.identifier.urihttps://hdl.handle.net/10321/3813-
dc.description.abstractAn anti-diabetic formulation consisting of vildagliptin and remogliflozin was prescribed for better glycemic control. In the present study a simple, rapid derivative spectrophotometric methods were evolved to analyze these two analytes from the formulations. Methods: Two processed UV spectrophotometric methods were established by measuring the peak amplitude at zero-crossing of second derivative spectra of analytes. The second procedure comprehends the generation of zero - order spectra from the mixture of analyte spectra by division and multiplication by the pure analyte spectra to remove the effect of one of the analytes. Results: Both methods showed linearity concentrations in the range of 2-75 µg/ml for RGF and 2-50 µg/ml for VGT. The low LOD and LOQ found for RGF and VGT by both methods indicated the good sensitivity of the methods. The mean percentage recovery was 98.60 % and 100.78%, for RGF and 98.81 % and 99.15 % for VGT, with low percent relative error. The % RSD for intra and inter-day precision was less than ±2%. Finally, the planned methods were employed for the assay of the VGT and RGF from the medicine and the outcomes were matched with the reported methods. Conclusion: The assay results of the formulation were in agreement with the concentration of labeled amount and no significant difference was observed in the results when compared to the reported method. Hence, the anticipated procedures could be applied for the routine quality control of formulations consisting of VGT and RGF.en_US
dc.format.extent8 pen_US
dc.language.isoenen_US
dc.publisherEManuscript Technologiesen_US
dc.relation.ispartofIndian Journal of Pharmaceutical Education and Research; Vol. 56, Issue 1en_US
dc.subject1115 Pharmacology and Pharmaceutical Sciencesen_US
dc.subjectAntidiabeticsen_US
dc.subjectVildagliptinen_US
dc.subjectRemogliflozinen_US
dc.subjectDerivative spectrophotometryen_US
dc.titleSmart spectrophotometric method development for simultaneous estimation of antidiabetic drugs in formulationsen_US
dc.typeArticleen_US
dc.date.updated2022-01-22T08:38:37Z-
dc.identifier.doi10.5530/ijper.56.1.26-
local.sdgSDG03-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextopen-
item.cerifentitytypePublications-
Appears in Collections:Research Publications (Applied Sciences)
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