Please use this identifier to cite or link to this item:
https://hdl.handle.net/10321/893
DC Field | Value | Language |
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dc.contributor.author | Raj, Raghu | en_US |
dc.contributor.author | Singh, Pardeep | en_US |
dc.contributor.author | Singh, Parvesh | en_US |
dc.contributor.author | Gut, Jiri | en_US |
dc.contributor.author | Rosenthal, Philip J. | en_US |
dc.contributor.author | Kumar, Vipan | en_US |
dc.date.accessioned | 2013-08-29T10:34:44Z | - |
dc.date.available | 2013-08-29T10:34:44Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.citation | Raja, R., Singh, P., Singh, P., Gutc, J., Rosenthalc, P.J. and Kumar, V. 2013. Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: Synthesis and antimalarial evaluation. European Journal of Medicinal Chemistry, 62: 590–596. | en_US |
dc.identifier.uri | http://hdl.handle.net/10321/893 | - |
dc.description.abstract | We describe the synthesis and antimalarial activities of 1H-1,2,3-triazole tethered 7-chloroquinoline-isatin hybrids. Activity against cultured parasites was dependent on the C-5 substituent of the isatin ring as well as the alkyl chain length between the isatin and 7-chloroquinoline moieties. Compound 8h, with an optimum alkyl chain length (n = 3) and a chloro substituent at the C-5 position of the isatin ring, displayed the best activity among the test compounds, with IC50 value of 1.21 μM against cultured W2-strain Plasmodium falciparum. | en_US |
dc.format.extent | 7 p | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | 7-Chloroquinoline-isatin conjugates | en_US |
dc.subject | 1H-1,2,3-triazole | en_US |
dc.subject | Antimalarial evaluation | en_US |
dc.subject | Structure–activity relationship | en_US |
dc.subject.lcsh | Malaria | en_US |
dc.title | Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras : synthesis and antimalarial evaluation | en_US |
dc.type | Article | en_US |
dc.publisher.uri | http://www.sciencedirect.com/science/article/pii/S0223523413000603/pdfft?md5=981f7a91cb361319d6a41ded99e81abd&pid=1-s2.0-S0223523413000603-main.pdf | en_US |
dc.dut-rims.pubnum | DUT-002772 | en_US |
dc.identifier.doi | 10.1016/ j.ejmech.2013.01.032 | - |
local.sdg | SDG03 | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
Appears in Collections: | Research Publications (Applied Sciences) |
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File | Description | Size | Format | |
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parvesh_2013_output.pdf | 2.05 MB | Adobe PDF | View/Open |
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