Please use this identifier to cite or link to this item:
https://hdl.handle.net/10321/1011
DC Field | Value | Language |
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dc.contributor.author | Adam, Jamila Khatoon | en_US |
dc.contributor.author | Pearce, A. | en_US |
dc.contributor.author | Naidoo, N. | en_US |
dc.contributor.author | Rmaih, Wafaa | en_US |
dc.date.accessioned | 2014-05-20T10:43:32Z | - |
dc.date.available | 2014-05-20T10:43:32Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Adam, J.K., Pearce, A., Naidoo, N., and Rmaih, W.N.S. 2012. The predictive value of proBNP levels to determine the presence and severity of coronary artery disease in patients with a positive or inconclusive exercise stress test. Medical Technology SA, 26(1): 13-17. | en_US |
dc.identifier.issn | 1011 5528 | - |
dc.identifier.uri | http://hdl.handle.net/10321/1011 | - |
dc.description.abstract | Background Several clinical studies have shown increased levels of N Terminal-Pronatriuretic Peptide (NT-proBNP) during epi- sodes of coronory ischaemia. Consistent with this observation, both Brain Natriuretic Peptide (BNP) and NT-proBNP correlated to severity, location, and extent of angiographic coronary artery disease (CAD). The main objective of this study was to identify the possible value of NT-proBNP level which indicates CAD. Methods Sixty patients with signs and symptoms of CAD were recruited for this study. They were divided into two groups; Group A, consisted of thirty patients with a positive Exercise Stress Test (EST) and Group B, consisted of thirty patients with an inconclusive EST. After the EST, all patients from both groups were required to have a NT-proBNP blood test, a left and right coronary angiogram and a left ventriculogram. Results Post EST NT-proBNP levels, in both groups, increased in the presence of CAD (p<0.001). For the positive EST group, the area under the ROC curve was 0.975 (p<0.001). A cut- off value of 120 pg/ml was identified with the highest sensitivity (95.7%) and specificity (100%). For patients in the inconclusive EST group, the area under the ROC curve was 0.912 (p<0.001). A cut-off value of 85 pg/ml was identified with the highest sensitivity (87.5%) and specificity (86.4%). Conclusion EST is relatively inaccurate at predicting CAD in patients with inconclusive ESTs. The need for an additional tool, such as NT-proBNP measurements post inconclusive EST is warranted in the determination of the presence of CAD. | en_US |
dc.format.extent | 5 p | en_US |
dc.language.iso | en | en_US |
dc.publisher | Medical Technology SA | en_US |
dc.relation.ispartof | Advances in bioscience and biotechnology (Print) | en_US |
dc.subject | BNP | en_US |
dc.subject | NT-ProBNP | en_US |
dc.subject | Exercise stress test | en_US |
dc.subject.lcsh | Coronory heart disease | en_US |
dc.subject.lcsh | Angiography | en_US |
dc.title | The predictive value of proBNP levels to determine the presence and severity of coronary artery disease in patients with a positive or inconclusive exercise stress test | en_US |
dc.type | Article | en_US |
dc.dut-rims.pubnum | DUT-001611 | en_US |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
Appears in Collections: | Research Publications (Health Sciences) |
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File | Description | Size | Format | |
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jk_adam__pearce_naidoo___rmaih_2012_output.pdf | 1.01 MB | Adobe PDF | View/Open |
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