Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/2978
DC FieldValueLanguage
dc.contributor.authorHolmen, Sigveen_US
dc.contributor.authorGalappaththi-Arachchigeen_US
dc.contributor.authorHashini Nilushikaen_US
dc.contributor.authorKleppa, Elisabethen_US
dc.contributor.authorPillay, Pavitraen_US
dc.contributor.authorNaicker, Thajasvarieen_US
dc.contributor.authorTaylor, Myraen_US
dc.contributor.authorOnsrud, Mathiasen_US
dc.contributor.authorKjetland, Eyrun Floereckeen_US
dc.contributor.authorAlbregtsen, Fritzen_US
dc.date.accessioned2018-05-22T09:08:07Z-
dc.date.available2018-05-22T09:08:07Z-
dc.date.issued2016-04-13-
dc.identifier.citationHolmen, S. et al. 2016. Characteristics of blood vessels in female genital schistosomiasis : paving the way for objective diagnostics at the point of care. PLOS Neglected Tropical Diseases. 10(4): 1-16. doi:10.1371/journal.pntd.0004628en_US
dc.identifier.issn1935-2727 (print)-
dc.identifier.issn1935-2735 (online)-
dc.identifier.urihttp://hdl.handle.net/10321/2978-
dc.description.abstractAbstract Background The mucosal changes associated with female genital schistosomiasis (FGS) encompass abnormal blood vessels. These have been described as circular, reticular, branched, convoluted and having uneven calibre. However, these characteristics are subjective descriptions and it has not been explored which of them are specific to FGS. Methods In colposcopic images of young women from a schistosomiasis endemic area, we performed computerised morphologic analyses of the cervical vasculature appearing on the mucosal surface. Study participants where the cervix was classified as normal served as negative controls, women with clinically diagnosed FGS and presence of typical abnormal blood vessels visible on the cervical surface served as positive cases. We also included women with cervical inflammatory conditions for reasons other than schistosomiasis. By automating morphological analyses, we explored circular configurations, vascular density, fractal dimensions and fractal lacunarity as parameters of interest. Results We found that the blood vessels typical of FGS are characterised by the presence of circular configurations (p < 0.001), increased vascular density (p = 0.015) and increased local connected fractal dimensions (p = 0.071). Using these features, we were able to correctly classify 78% of the FGS-positive cases with an accuracy of 80%. Conclusions The blood vessels typical of FGS have circular configurations, increased vascular density and increased local connected fractal dimensions. These specific morphological features could be used diagnostically. Combined with colourimetric analyses, this represents a step towards making a diagnostic tool for FGS based on computerised image analysis.en_US
dc.format.extent16 pen_US
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofPLoS neglected tropical diseases (Online)en_US
dc.titleCharacteristics of blood vessels in female genital schistosomiasis : paving the way for objective diagnostics at the point of careen_US
dc.typeArticleen_US
dc.publisher.urihttp://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004628&type=printableen_US
dc.dut-rims.pubnumDUT-005813en_US
dc.identifier.doi10.1371/journal.pntd.0004628-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.languageiso639-1en-
Appears in Collections:Research Publications (Health Sciences)
Files in This Item:
File Description SizeFormat
Holmen_PNTD_Vol10#4_16Pgs_2016.pdf717.27 kBAdobe PDFThumbnail
View/Open
Show simple item record

Page view(s)

720
checked on Dec 22, 2024

Download(s)

254
checked on Dec 22, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.