Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/882
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dc.contributor.authorReddy, Poovendhreeen_US
dc.contributor.authorNaidoo, Rajen N.en_US
dc.contributor.authorChuturgoon, Anil A.en_US
dc.contributor.authorAsharam, Kareshmaen_US
dc.contributor.authorNaidoo, Dhaneshreeen_US
dc.contributor.authorPhulukdaree, Alisaen_US
dc.contributor.authorGounden, Shivonaen_US
dc.date.accessioned2013-08-06T07:47:39Z
dc.date.available2013-08-06T07:47:39Z
dc.date.issued2013-03-
dc.identifier.citationReddy, P.; Naidoo, R.N.; Chuturgoon, A.; Asharam, K.; Naidoo, D.; Phulukdaree, A. and Gounden, S. 2013. 'Correlation between glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase pi gene (GSTP1) polymorphisms and markers of inflammatory stress in pregnant females' Journal of Toxicology and Environmental Health Sciences, 6(3): 52-59.en_US
dc.identifier.urihttp://hdl.handle.net/10321/882-
dc.description.abstractThe Mother and Child Environmental Cohort (MACE) study piloted in South Africa in 2010 to 2011, collected genetic, biochemical and clinical data from pregnant females residing in south and north Durban. We evaluated birth outcomes and the influence of GSTM1pos→GSTM1null and the GSTP1 (Ile105Val; AA→AG/GG) polymorphisms on the extent of DNA damage and with biomarkers [glutathione (GSH) and malondialdehyde (MDA)] related to oxidative stress in mothers with different levels of pollutant exposure. There was no significant difference in adverse birth outcomes or genotype distribution between mothers from the exposed and lower exposed areas. Mean GSH and comet tail length did not differ significantly between GSTM1pos and GSTM1null genotypes. When stratified by genotype, mean MDA levels was higher among GSTM1 null mothers compared to the GSTM1pos mothers (p = 0.01). When each of the genotypes was stratified by exposure, mean GSH concentration was significantly higher in north Durban for the GSTM1pos, GSTM1null and GSTP1AG+GG genotypes (p < 0.05), and mean comet tail length was significantly increased in south Durban among participants with the GSTM1pos, GSTM1null, and the GSTP1AG+GG genotypes. The expression of GSTM1 and GSTP1 polymorphic genotypes may lead to varying susceptibility to the adverse effects of pollutants by modifying the response to oxidative stress.en_US
dc.format.extent8 pen_US
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.subjectGlutathione S-transferase Mu 1 (GSTM1)en_US
dc.subjectGlutathione S-transferase pi gene (GSTP1)en_US
dc.subjectBirth cohorten_US
dc.subjectGene polymorphismen_US
dc.subject.lcshOxidative stressen_US
dc.subject.lcshGlutathioneen_US
dc.subject.lcshDNA damageen_US
dc.titleCorrelation between glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase pi gene (GSTP1) polymorphisms and markers of inflammatory stress in pregnant femalesen_US
dc.typeArticleen_US
dc.publisher.urihttp://www.academicjournals.org/JTEHS/PDF/Pdf2013/Mar/Poovendhree%20et%20al.pdfen_US
dc.dut-rims.pubnumDUT-002500en_US
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item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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