Please use this identifier to cite or link to this item:
https://hdl.handle.net/10321/907
DC Field | Value | Language |
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dc.contributor.author | Gaziano, Thomas A. | en_US |
dc.contributor.author | Pandya, Ankur | en_US |
dc.contributor.author | Steyn, Krisela | en_US |
dc.contributor.author | Levitt, Naomi | en_US |
dc.contributor.author | Mollentze, Willie | en_US |
dc.contributor.author | Joubert, Gina | en_US |
dc.contributor.author | Walsh, Corinna M | en_US |
dc.contributor.author | Motala, Ayesha A. | en_US |
dc.contributor.author | Kruger, Annamarie | en_US |
dc.contributor.author | Schutte, Aletta E. | en_US |
dc.contributor.author | Naidoo, Datshana Prakash | en_US |
dc.contributor.author | Prakaschandra, Dorcas Rosaley | en_US |
dc.contributor.author | Laubscher, Ria | en_US |
dc.date.accessioned | 2013-09-16T13:54:20Z | - |
dc.date.available | 2013-09-16T13:54:20Z | - |
dc.date.issued | 2013-07-24 | - |
dc.identifier.citation | Gaziano, T.A., Pandya, A., Steyn, K., Levitt, N., Mollentze, W., Joubert, G., Walsh, C.M.,,Motala, A.A., Kruger, A., Schutte, A.E.; Naidoo, D.P.; Prakaschandra, D.R. and Laubscher, R. 2013. Comparative assessment of absolute cardiovascular disease risk characterization from non-laboratory- based risk assessment in South African populations. BMC Medicine, 11(170). | en_US |
dc.identifier.uri | http://hdl.handle.net/10321/907 | - |
dc.description.abstract | Background All rigorous primary cardiovascular disease (CVD) prevention guidelines recommend absolute CVD risk scores to identify high- and low-risk patients, but laboratory testing can be impractical in low- and middle-income countries. The purpose of this study was to compare the ranking performance of a simple, non-laboratory-based risk score to laboratory-based scores in various South African populations. Methods We calculated and compared 10-year CVD (or coronary heart disease (CHD)) risk for 14,772 adults from thirteen cross-sectional South African populations (data collected from 1987 to 2009). Risk characterization performance for the non-laboratory-based score was assessed by comparing rankings of risk with six laboratory-based scores (three versions of Framingham risk, SCORE for high- and low-risk countries, and CUORE) using Spearman rank correlation and percent of population equivalently characterized as ‘high’ or ‘low’ risk. Total 10-year non-laboratory-based risk of CVD death was also calculated for a representative cross-section from the 1998 South African Demographic Health Survey (DHS, n = 9,379) to estimate the national burden of CVD mortality risk. Results Spearman correlation coefficients for the non-laboratory-based score with the laboratory-based scores ranged from 0.88 to 0.986. Using conventional thresholds for CVD risk (10% to 20% 10-year CVD risk), 90% to 92% of men and 94% to 97% of women were equivalently characterized as ‘high’ or ‘low’ risk using the non-laboratory-based and Framingham (2008) CVD risk score. These results were robust across the six risk scores evaluated and the thirteen cross-sectional datasets, with few exceptions (lower agreement between the non-laboratory-based and Framingham (1991) CHD risk scores). Approximately 18% of adults in the DHS population were characterized as ‘high CVD risk’ (10-year CVD death risk >20%) using the non-laboratory-based score. Conclusions We found a high level of correlation between a simple, non-laboratory-based CVD risk score and commonly-used laboratory-based risk scores. The burden of CVD mortality risk was high for men and women in South Africa. The policy and clinical implications are that fast, low-cost screening tools can lead to similar risk assessment results compared to time- and resource-intensive approaches. Until setting-specific cohort studies can derive and validate country-specific risk scores, non-laboratory-based CVD risk assessment could be an effective and efficient primary CVD screening approach in South Africa. | en_US |
dc.format.extent | 23 p | en_US |
dc.language.iso | en | en_US |
dc.publisher | BioMed Central | en_US |
dc.subject.lcsh | Cardiovascular system--Diseases--Risk factors | en_US |
dc.subject.lcsh | Cardiovascular system--Diseases--Prevention | en_US |
dc.subject.lcsh | Cholesterol | en_US |
dc.subject.lcsh | Cerebrovascular disease | en_US |
dc.subject.lcsh | Coronary heart disease | en_US |
dc.title | Comparative assessment of absolute cardiovascular disease risk characterization from non-laboratory- based risk assessment in South African populations | en_US |
dc.type | Article | en_US |
dc.publisher.uri | http://dx.doi.org/10.1186/1741-7015-11-170 | en_US |
dc.dut-rims.pubnum | DUT-002876 | en_US |
dc.identifier.doi | 10.1186/1741-7015-11-170 | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Research Publications (Health Sciences) |
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bmc_medicine_dorcas_r_prakaschandra.pdf | 2.05 MB | Adobe PDF | View/Open |
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